Becas y oportunidades de trabajo

POSTDOCTORAL POSITION IN ANTI-TUMOR IMMUNOTHERAPY

Location: INSERM U932, Institut Curie, Paris, France
Date posted: JULY 2021
Application deadline: SEPTEMBER 2021

Job description summary
The research group of Dr Philippe Benaroch (http://ow.ly/WjoV50yVbOQ) is seeking a PhD-qualified scientist. The candidate will join the ongoing project which aims at further developing a human adoptive cell therapy platform to treat solid tumors based on genetic engineering of primary myeloid cells. The candidate will be in charge of designing and performing preclinical in vivo experiments with immunodeficient mice carrying human tumors.


Context
The Benaroch’s team is part of a 130-person Immunology department (Inserm U932, Paris, France) headed by Dr Anna-Maria Lennon at Institut Curie. The team is focused on myeloid cells that represent a very ancient form of cellular immunity against pathogens and tumor cells. They are very plastic, endowed with an ever-growing list of functions in innate and adaptive immunity. How myeloid cells crosstalk with viruses and tumor cells, and how this interplay is regulated remain to be established at the molecular level and represent the focus of his lab. The team offers the opportunity to expand and develop your career in the exciting professional environment of Institut Curie promoted by an open culture and a spirit of community. Institut Curie is one of the largest European institutions for cancer and biomedical research with strong interdisciplinary traditions. It is equipped with state-of-the-art facilities (imaging, proteomic, animal facility, genomic and cytometry platforms).


Project
Solid cancers are shaped by a complex tumor microenvironment (TME) that critically impacts their growth and metastatic potential, as well as their response to therapies. Myeloid cells shape the TME and are major players in immune resistance and/or evasion mechanisms. Myeloid cells have a great capacity to phagocytose dead and even living cells, including tumor cells. This activity is coupled to their antigen presentation function which can stimulate the adaptive immune response. Harnessing their plasticity and functional properties, we aim to use myeloid cells as anti-tumor therapeutic agents following their genetic engineering. This should stimulate the anti-tumor response and counteract the immunosuppressive activity of myeloid cells in the TME. By combining state-of-the-art
technologies in molecular biology and cell biology with in vivo experimental approaches, we plan to reinforce our preliminary results and develop optimized myeloid cells as anti-cancer adoptive cell therapy.

Profile
Qualification:
• PhD in Immunology, experience with mouse models (i.v tail injections, harvesting lymphoid organs, training in animal experimentation) and with multicolor FACS analyses
• Some knowledge in cancer biology and cell biology is not mandatory but will be highly appreciated

Desirable Knowledge, skills and abilities:
• Scientific rigor and excellent analytical and synthetic capabilities
• Team spirit, and dynamic personality with passion for innovation and problem-solving
18 months already funded with possible extension.
Please send CV and two letters of reference to maude.delost@curie.fr AND TO philippe.benaroch@curie.fr

RESEARCH ENGINEER IN IMMUNOLOGY

RESEARCH ENGINEER IN IMMUNOLOGY

Open position: Research engineer with a PhD and experience in immunology

Location: U932, Team TransImm, Institut Curie, Paris, France

Date posted: July 2021

Application deadline: October 2021

Job description

The research group of Dr. Eliane Piaggio (Inserm U932, Paris, France) is seeking a degree-qualified  research engineer. The research engineer will be dedicated to work on several projects in the frame of fundamental and translational immunology research studying different immunotherapeutic approaches in mouse preclinical models, mainly in humanized NSG mouse models. The applicant will be in charge of developing, handling, analyzing the experiments and follow the bibliography.

The initial contract is for 3 years.

Context

Projects will be developed under the supervision of Dr Eliane Piaggio leading the team “Translational Immunotherapy” (https://science.curie.fr/recherche/biologie-interactive-des-tumeurs-immunologie-environnement/immunite-et-cancer/equipe-piaggio-loirat/) and Dr Christine Sedlik, senior research engineer.

The team encompasses 10 members, including two bioinformaticians and a project manager.

The group is part of a 130-person immunology department headed by Anna-Maria Lennon. The lab is located within the Institut Curie campus in the center of Paris.  The building is equipped with state of the art facilities (imaging, proteomic, animal facility, genomic and cytometry platforms). The Institute hosts around 1500 bench scientists including many foreign students and post-doctoral fellows.

Profile

Qualification:

  • PhD in immunology and demonstrated success in a previous research experience in immunology testified by publications
  • Experience in humanized NSG mice would be appreciated

Technical skills and abilities:

  • Expert in mouse experimentation (1st/2nd level of authorization)
  • Expert in multiparametric FACS
  • Cell culture, ELISA, ELISPOT…
  • Strong motivation, autonomy and excellent team working skills
  • High standards of integrity, accuracy and great rigor are essential
  • Good proficiency in English is mandatory

Please send CV and motivation letter to jeremie.goldstein@curie.fr

POST-DOCTORANT IN IMMUNOLOGY

POST-DOCTORANT IN IMMUNOLOGY

Open position: Post-doctorant in immunology

Location: Unit INSERMU932, Team TransImm, Institut Curie, Paris, France

Date posted: July 2021

Application deadline: October 2021

Job description

The research group of Dr. Eliane Piaggio (Inserm U932, Paris, France) is seeking a degree-qualified  post-doctorant. The candidate will be dedicated to work on several projects in the frame of fundamental and translational immunology research, related to CD4+ Tregs biology in cancer clinical studies. The applicant will be in charge of developing, handling, analyzing the experiments and follow the bibliography.

The initial contract is for 3 years.

Context

Projects will be developed under the supervision of Dr Eliane Piaggio leading the team “Translational Immunotherapy” (https://science.curie.fr/recherche/biologie-interactive-des-tumeurs-immunologie-environnement/immunite-et-cancer/equipe-piaggio-loirat/).

The team encompasses 10 members, including two bioinformaticians and a project manager.

The group is part of a 130-person immunology department headed by Anna-Maria Lennon. The lab is located within the Institut Curie campus in the center of Paris.  The building is equipped with state of the art facilities (imaging, proteomic, animal facility, genomic and cytometry platforms). The Institute hosts around 1500 bench scientists including many foreign students and post-doctoral fellows.

Profile

Qualification:

  • PhD in immunology
  • Demonstrated success in a previous research experience testified by publications
  • Knowledge and experience on CD4+ Tregs biology will be a plus

Technical skills and abilities:

  • Expert in multiparametric FACS
  • Experience in analysis of next generation sequencing techniques (scRNASeq, ATACSeq, TCRSeq…) will be a plus
  • Strong motivation, autonomy and excellent team working skills
  • High standards of integrity, accuracy and great rigor are essential
  • Good proficiency in English is mandatory

Please send CV and motivation letter to jeremie.goldstein@curie.fr

BIOINFORMATICIAN IN IMMUNOLOGY

BIOINFORMATICIAN IN IMMUNOLOGY

Open positions: Senior bioinformatician with a PhD and experience in immunology

Location: U932, Team TransImm, Institut Curie, Paris, France

Date posted: July 2021

Application deadline: October 2021

Job description summary

The research group of Dr. Eliane Piaggio (Inserm U932, Paris, France) is seeking a degree-qualified  computational scientist. The bioinformatician will be dedicated to work on several projets in the frame of fundamental and translational immunology research projects regarding neoantigen epitope prediction, CD8+ and CD4+ Tconv and Tregs cell biology and anti-tumor responses. This will require analysis of large datasets generated from single cell RNAseq associated with TCRseq, single cell ATACseq, whole exome sequencing and bulk expression studies. The candidate will have to supervise the work of other junior bio-informaticians. The initial contract is for 3 years.

Context

Projects will be developped under the supervision of Dr Eliane Piaggio leading the team “Translational Immunotherapy” (https://science.curie.fr/recherche/biologie-interactive-des-tumeurs-immunologie-environnement/immunite-et-cancer/equipe-piaggio-loirat/).

The team encompasses: 2 postdocs, 3 PhD students (including a bioinformatician), 1 technician and 4 engineers (including a bioinformatician and a project manager). The team generate large datasets such as bulk and single cell transcriptomics.

The group is part of a 130-person immunology department headed by Anna-Maria Lennon. The lab is located within the Institut Curie campus in the center of Paris.  The building is equipped with state of the art facilities (imaging, proteomic, animal facility, genomic and cytometry platforms). The Institute hosts around 1500 bench scientists including many foreign post-doctoral fellows.

Profile

Candidates will have a Ph.D. in bioinformatics, mathematics, computer science, or related field. She/he should have demonstrated success in a previous research experience in immunology-applied bioinformatics and statistics testified by publications.

Knowledge in approaches for high-throughput data analysis, statistical modeling, and classification as well as some knowledge in immunology are required.

Strong motivation, autonomy and ability to quickly and effectively adapt to new projects will be essential.

Good proficiency in English is mandatory.

Please send CV and motivation letter to jeremie.goldstein@curie.fr

CONICET 2021

Se busca postulante para presentar en la próxima convocatoria a becas doctorales de CONICET 2021. Preferentemente Graduado/a o alumno/a próximo a graduarse de las carreras de Biología, Bioquímica, Biotecnología, Farmacia o afines con entusiasmo para realizar tesis doctoral.

Lugar de Trabajo: Instituto de Inmunología, Genetica y Metabolismo (INIGEM, CONICET-UBA; https://inigem-uba.conicet.gov.ar/).

Tema: Inmunopatología de la Brucelosis. Implicancias en sistema nervioso central.

Hemos descripto que Brucella abortus ocasiona muerte neuronal mediada por la microglía activada. Estudiaremos diferentes vías de regulación de este mecanismo de inmunopatogenia desencadenado en el SNC durante la neurobrucelosis.

Duración: 5 años con comienzo el 1 abril 2022
Investigadores Responsables: Dra. Ana María Rodríguez y Dr. Guillermo Giambartolomei

Enviar CV (incluyendo promedio, aplazos y materias adeudadas) a: amrodriguez@fmed.uba.ar y/o ggiambart@ffyb.uba.ar

Convocatoria a aspirantes a Beca Doctoral 2021-2026 asociada a PUE2020 (IMTIB, CONICET – IUHI – HIBA)

Convocatoria a aspirantes a Beca Doctoral 2021-2026 asociada a PUE2020 (IMTIB, CONICET – IUHI
– HIBA)


Título de la Beca: “Estudio del microbioma intestinal y su asociación con el hígado graso no alcohólico en Argentina”.
Directora: Dra. Julieta Trinks
El plan de beca se desarrollará en el marco del PUE “Investigación Traslacional en Microbioma:
caracterización taxonómica en diferentes contextos clínicos de alta prevalencia”, cuyo objetivo general es analizar la taxonomía del microbioma intestinal (a través del estudio metagenómico del
ARNr 16S) para caracterizar e identificar potenciales nuevos biomarcadores que sean aplicables en diferentes contextos clínicos. En consecuencia, este plan se propone caracterizar el microbioma
intestinal bacteriano y su impacto en la progresión del hígado graso no alcohólico en 100 pacientes con distintos estadios de la enfermedad y 50 voluntarios sanos. Por otro lado, a partir de los
resultados obtenidos, y dado que la fisiopatogenia de esta patología se basa en una interacción equilibrada y compleja entre el microbioma intestinal, el estilo de vida y la genética del individuo, se
propone establecer posibles asociaciones entre el microbioma intestinal, datos clínicos y factores genéticos del hospedador con la progresión clínica de dicha enfermedad.

Lugar de trabajo: Instituto de Medicina Traslacional e Ingeniería Biomédica (IMTIB), CONICET, Instituto Universitario del Hospital Italiano, Hospital Italiano de Buenos Aires.

Requisitos:
• Para la beca doctoral el/la postulante deberá estar graduado/a de carreras afines a las ciencias biológicas y de la salud (Medicina, Bioquímica, Lic. En Biología, Lic. En Biotecnología, etc.), o
ser estudiante de dichas carreras y adeude una materia o el trabajo final con fecha de graduación antes del 31 de mayo de 2021.
• Preferentemente con experiencia previa en investigación, no excluyente.
• El/la postulante deberá mostrar aptitud para trabajar en equipo y motivación por la investigación científica aplicada.
• Compromiso para desarrollar el proyecto en tiempo y forma.
• Manejo oral y escrito de idioma inglés.
• Promedio de la carrera mayor a 7.

Características de la beca: Beca para iniciar trabajo de tesis doctoral. Dedicación exclusiva, 40 horas semanales, sólo compatible con el ejercicio de un (1) cargo docente de dedicación simple.
Contacto: Los/las interesados/as deberán enviar un mail adjuntando: 1) Carta señalando las motivaciones para realizar un doctorado en el tema propuesto, 2) CV del postulante 3) Certificado de
materias cursadas, notas incluyendo aplazos, al e-mail: julieta.trinks@hospitalitaliano.org.ar

Posición post-doctoral

Posición post-doctoral disponible a partir de junio 2021 en el laboratorio de la Dra. Adriana Mantegazza, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Nuestro laboratorio investiga respuestas inmunes innatas y adaptativas en células dendríticas murinas y humanas. En particular estudiamos el cross-talk entre la fagocitosis y la activación del
inflamasoma, y la regulación de estos procesos, con el fin de modular respuestas inmunes.

El proyecto post-doctoral consistirá en estudiar el mecanismo de acción de proteínas candidatas en la regulación de la actividad del inflamasoma y la inducción de autofagia en células dendríticas.

Interesados en conocer más sobre el proyecto, la Universidad, la ciudad, y en formar parte del grupo contactarse con: adriana.mantegazza@jefferson.edu.