POSTDOCTORAL POSITION IN ANTI-TUMOR IMMUNOTHERAPY

Location: INSERM U932, Institut Curie, Paris, France
Date posted: JULY 2021
Application deadline: SEPTEMBER 2021

Job description summary
The research group of Dr Philippe Benaroch (http://ow.ly/WjoV50yVbOQ) is seeking a PhD-qualified scientist. The candidate will join the ongoing project which aims at further developing a human adoptive cell therapy platform to treat solid tumors based on genetic engineering of primary myeloid cells. The candidate will be in charge of designing and performing preclinical in vivo experiments with immunodeficient mice carrying human tumors.


Context
The Benaroch’s team is part of a 130-person Immunology department (Inserm U932, Paris, France) headed by Dr Anna-Maria Lennon at Institut Curie. The team is focused on myeloid cells that represent a very ancient form of cellular immunity against pathogens and tumor cells. They are very plastic, endowed with an ever-growing list of functions in innate and adaptive immunity. How myeloid cells crosstalk with viruses and tumor cells, and how this interplay is regulated remain to be established at the molecular level and represent the focus of his lab. The team offers the opportunity to expand and develop your career in the exciting professional environment of Institut Curie promoted by an open culture and a spirit of community. Institut Curie is one of the largest European institutions for cancer and biomedical research with strong interdisciplinary traditions. It is equipped with state-of-the-art facilities (imaging, proteomic, animal facility, genomic and cytometry platforms).


Project
Solid cancers are shaped by a complex tumor microenvironment (TME) that critically impacts their growth and metastatic potential, as well as their response to therapies. Myeloid cells shape the TME and are major players in immune resistance and/or evasion mechanisms. Myeloid cells have a great capacity to phagocytose dead and even living cells, including tumor cells. This activity is coupled to their antigen presentation function which can stimulate the adaptive immune response. Harnessing their plasticity and functional properties, we aim to use myeloid cells as anti-tumor therapeutic agents following their genetic engineering. This should stimulate the anti-tumor response and counteract the immunosuppressive activity of myeloid cells in the TME. By combining state-of-the-art
technologies in molecular biology and cell biology with in vivo experimental approaches, we plan to reinforce our preliminary results and develop optimized myeloid cells as anti-cancer adoptive cell therapy.

Profile
Qualification:
• PhD in Immunology, experience with mouse models (i.v tail injections, harvesting lymphoid organs, training in animal experimentation) and with multicolor FACS analyses
• Some knowledge in cancer biology and cell biology is not mandatory but will be highly appreciated

Desirable Knowledge, skills and abilities:
• Scientific rigor and excellent analytical and synthetic capabilities
• Team spirit, and dynamic personality with passion for innovation and problem-solving
18 months already funded with possible extension.
Please send CV and two letters of reference to maude.delost@curie.fr AND TO philippe.benaroch@curie.fr

RESEARCH ENGINEER IN IMMUNOLOGY

RESEARCH ENGINEER IN IMMUNOLOGY

Open position: Research engineer with a PhD and experience in immunology

Location: U932, Team TransImm, Institut Curie, Paris, France

Date posted: July 2021

Application deadline: October 2021

Job description

The research group of Dr. Eliane Piaggio (Inserm U932, Paris, France) is seeking a degree-qualified  research engineer. The research engineer will be dedicated to work on several projects in the frame of fundamental and translational immunology research studying different immunotherapeutic approaches in mouse preclinical models, mainly in humanized NSG mouse models. The applicant will be in charge of developing, handling, analyzing the experiments and follow the bibliography.

The initial contract is for 3 years.

Context

Projects will be developed under the supervision of Dr Eliane Piaggio leading the team “Translational Immunotherapy” (https://science.curie.fr/recherche/biologie-interactive-des-tumeurs-immunologie-environnement/immunite-et-cancer/equipe-piaggio-loirat/) and Dr Christine Sedlik, senior research engineer.

The team encompasses 10 members, including two bioinformaticians and a project manager.

The group is part of a 130-person immunology department headed by Anna-Maria Lennon. The lab is located within the Institut Curie campus in the center of Paris.  The building is equipped with state of the art facilities (imaging, proteomic, animal facility, genomic and cytometry platforms). The Institute hosts around 1500 bench scientists including many foreign students and post-doctoral fellows.

Profile

Qualification:

  • PhD in immunology and demonstrated success in a previous research experience in immunology testified by publications
  • Experience in humanized NSG mice would be appreciated

Technical skills and abilities:

  • Expert in mouse experimentation (1st/2nd level of authorization)
  • Expert in multiparametric FACS
  • Cell culture, ELISA, ELISPOT…
  • Strong motivation, autonomy and excellent team working skills
  • High standards of integrity, accuracy and great rigor are essential
  • Good proficiency in English is mandatory

Please send CV and motivation letter to jeremie.goldstein@curie.fr

POST-DOCTORANT IN IMMUNOLOGY

POST-DOCTORANT IN IMMUNOLOGY

Open position: Post-doctorant in immunology

Location: Unit INSERMU932, Team TransImm, Institut Curie, Paris, France

Date posted: July 2021

Application deadline: October 2021

Job description

The research group of Dr. Eliane Piaggio (Inserm U932, Paris, France) is seeking a degree-qualified  post-doctorant. The candidate will be dedicated to work on several projects in the frame of fundamental and translational immunology research, related to CD4+ Tregs biology in cancer clinical studies. The applicant will be in charge of developing, handling, analyzing the experiments and follow the bibliography.

The initial contract is for 3 years.

Context

Projects will be developed under the supervision of Dr Eliane Piaggio leading the team “Translational Immunotherapy” (https://science.curie.fr/recherche/biologie-interactive-des-tumeurs-immunologie-environnement/immunite-et-cancer/equipe-piaggio-loirat/).

The team encompasses 10 members, including two bioinformaticians and a project manager.

The group is part of a 130-person immunology department headed by Anna-Maria Lennon. The lab is located within the Institut Curie campus in the center of Paris.  The building is equipped with state of the art facilities (imaging, proteomic, animal facility, genomic and cytometry platforms). The Institute hosts around 1500 bench scientists including many foreign students and post-doctoral fellows.

Profile

Qualification:

  • PhD in immunology
  • Demonstrated success in a previous research experience testified by publications
  • Knowledge and experience on CD4+ Tregs biology will be a plus

Technical skills and abilities:

  • Expert in multiparametric FACS
  • Experience in analysis of next generation sequencing techniques (scRNASeq, ATACSeq, TCRSeq…) will be a plus
  • Strong motivation, autonomy and excellent team working skills
  • High standards of integrity, accuracy and great rigor are essential
  • Good proficiency in English is mandatory

Please send CV and motivation letter to jeremie.goldstein@curie.fr

BIOINFORMATICIAN IN IMMUNOLOGY

BIOINFORMATICIAN IN IMMUNOLOGY

Open positions: Senior bioinformatician with a PhD and experience in immunology

Location: U932, Team TransImm, Institut Curie, Paris, France

Date posted: July 2021

Application deadline: October 2021

Job description summary

The research group of Dr. Eliane Piaggio (Inserm U932, Paris, France) is seeking a degree-qualified  computational scientist. The bioinformatician will be dedicated to work on several projets in the frame of fundamental and translational immunology research projects regarding neoantigen epitope prediction, CD8+ and CD4+ Tconv and Tregs cell biology and anti-tumor responses. This will require analysis of large datasets generated from single cell RNAseq associated with TCRseq, single cell ATACseq, whole exome sequencing and bulk expression studies. The candidate will have to supervise the work of other junior bio-informaticians. The initial contract is for 3 years.

Context

Projects will be developped under the supervision of Dr Eliane Piaggio leading the team “Translational Immunotherapy” (https://science.curie.fr/recherche/biologie-interactive-des-tumeurs-immunologie-environnement/immunite-et-cancer/equipe-piaggio-loirat/).

The team encompasses: 2 postdocs, 3 PhD students (including a bioinformatician), 1 technician and 4 engineers (including a bioinformatician and a project manager). The team generate large datasets such as bulk and single cell transcriptomics.

The group is part of a 130-person immunology department headed by Anna-Maria Lennon. The lab is located within the Institut Curie campus in the center of Paris.  The building is equipped with state of the art facilities (imaging, proteomic, animal facility, genomic and cytometry platforms). The Institute hosts around 1500 bench scientists including many foreign post-doctoral fellows.

Profile

Candidates will have a Ph.D. in bioinformatics, mathematics, computer science, or related field. She/he should have demonstrated success in a previous research experience in immunology-applied bioinformatics and statistics testified by publications.

Knowledge in approaches for high-throughput data analysis, statistical modeling, and classification as well as some knowledge in immunology are required.

Strong motivation, autonomy and ability to quickly and effectively adapt to new projects will be essential.

Good proficiency in English is mandatory.

Please send CV and motivation letter to jeremie.goldstein@curie.fr

Posición post-doctoral

Posición post-doctoral disponible a partir de junio 2021 en el laboratorio de la Dra. Adriana Mantegazza, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Nuestro laboratorio investiga respuestas inmunes innatas y adaptativas en células dendríticas murinas y humanas. En particular estudiamos el cross-talk entre la fagocitosis y la activación del
inflamasoma, y la regulación de estos procesos, con el fin de modular respuestas inmunes.

El proyecto post-doctoral consistirá en estudiar el mecanismo de acción de proteínas candidatas en la regulación de la actividad del inflamasoma y la inducción de autofagia en células dendríticas.

Interesados en conocer más sobre el proyecto, la Universidad, la ciudad, y en formar parte del grupo contactarse con: adriana.mantegazza@jefferson.edu.

Doctor en Ciencias Químicas, Bioquímica, Biología, Biomédicas o similares

Buscamos:

Doctor en Ciencias Químicas, Bioquímica, Biología, Biomédicas o similares. 

Tema: Trisomía 21 y sistema inmune

Investigadora responsable: Mariana Maccioni

Enviar CV  amariana.maccioni@unc.edu.ar

Estudiante avanzado o profesional recientemente recibido

Buscamos: estudiante avanzado o profesional recientemente recibido de Lic. Cs. Biológicas, Biotecnología, Ing. Genética o carreras afines para realizar tesis doctoral o estancia postdoc.
Tema:  Inmunopatología de la Brucelosis en Sistema Nervioso Central
Investigadores responsables: ️Dr.Guillermo Giambartolomei (Investigador Principal-CONICET) y ️Dra.Ana María Rodríguez (Investigadora Adjunta-CONICET). Lugar de Trabajo: INIGEM- Hospital de Clínicas, CABA.
Interesados enviar CV a amrodriguez@fmed.uba.ar y ggiambart@ffyb.uba.ar

Búsqueda de estrategias que logren revertir la resistencia al tratamiento inducido por el microambiente tumoral en leucemia linfática crónica

Lugar de trabajo: Laboratorio de Inmunología Oncológica.
IMEX-CONICET-ANM, CABA.
Directora: Dra. Romina Gamberale.
Duración de la beca: 2 años (empezaremos a trabajar apenas podamos volver al laboratorio!)

Requisitos: Doctor en Biología, Bioquímica, Biotecnología, Medicina o carreras afines, con dominio del idioma inglés, capacidad para trabajar en equipo y vocación científica. Se valorará positivamente que el postulante tenga experiencia previa en trabajo con ratones.
La persona interesada deberá enviar por e-mail a la Dra. Romina Gamberale (rominagamberale@gmail.com):
1) una carta de motivación, 2) CV completo y 3) dos cartas de referencia.

Llamado a Postdoc en el Institut Pasteur de Montevideo

Llamado a Postdoc en el Institut Pasteur de Montevideo
El Institut Pasteur de Montevideo, Uruguay realiza un llamado abierto para incorporar a un/a investigador/a postdoctoral al laboratorio de Investigación en Leucemia Linfoide Crónica (iLLC).
Formación alcanzada:
El/La postulante deberá contar con formación doctoral y poseer como mínimo dos artículos de 1er autor en revistas de referato internacional.
Experiencia:
Se considerará oportuna, pero no excluyente, la experiencia en biología celular y molecular así como conocimientos en el área de inmunología y oncología.
Responsabilidades:
La persona seleccionada liderará un proyecto en el laboratorio iLLC enmarcado en una colaboración científica con la plataforma de Tecnología y Ciencia de Glaxo
Smith Kline (GSK). Dicho proyecto estará centrado en el área de la inmunooncología, haciendo foco en la comprensión de los mecanismos moleculares de la progresión leucémica y el descubrimiento de nuevas estrategias terapéuticas para las neoplasias linfoides. Se utilizarán principalmente técnicas de citometría de flujo, microscopia confocal, PCR cuantitativa y análisis transcriptómicos de única célula.

Duración:
El cargo es de dedicación exclusiva y tendrá una duración de dos años. Será financiado por GSK, existiendo posteriormente la posibilidad de extender la posición por dos años adicionales, con financiamiento institucional concursable.
Los/Las aspirantes deberán enviar sus postulaciones a: llamados@pasteur.edu.uy haciendo referencia al número del llamado y en formato pdf, los siguientes documentos:
a) Carta de motivación
b) Curriculum vitae resumido conteniendo la siguiente información:
• Datos Personales
• Formación Académica
• Antecedentes laborales científicos
• Lista de publicaciones
• Presentaciones orales en congresos
• Premios y/o becas científicas
c) Dos cartas de recomendación (académicas).
El plazo de recepción de postulaciones vence el Lunes 07 de Setiembre de 2020.

El Institut Pasteur de Montevideo es una institución comprometida con la promoción de una cultura organizacional con equidad de género. La Institución adhiere a la Ley 17.817 sobre lucha contra el racismo, xenofobia y toda otra forma de discriminación y la Ley Nº 18.104 sobre igualdad de derechos y oportunidades entre hombres y mujeres